Related references
Note: Only part of the references are listed.Can Silicon Make an Excellent Drug Even Better? An in vitro and in vivo Head-to-Head Comparison between Loperamide and Its Silicon Analogue Sila-Loperamide
Marcel Geyer et al.
CHEMMEDCHEM (2015)
Si- and C-Functional Organosilicon Building Blocks for Synthesis Based on 4-Silacyclohexan-1-ones Containing the Silicon Protecting Groups MOP (4-Methoxyphenyl), DMOP (2,6-Dimethoxyphenyl), or TMOP (2,4,6-Trimethoxyphenyl)
Marcel Geyer et al.
JOURNAL OF ORGANIC CHEMISTRY (2015)
Invariom based electron density studies on the C/Si analogues haloperidol/sila-haloperidol and venlafaxine/sila-venlafaxine
Peter Luger et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2015)
Synthesis and evaluation of (E)-2-(acrylamido)cyclohex-1-enecarboxylic acid derivatives as HCA1, HCA2, and HCA3 receptor agonists
Olga Bobileva et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2014)
Identification of a novel GPR81-selective agonist that suppresses lipolysis in mice without cutaneous flushing
Taku Sakurai et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2014)
Synthesis of 4-Silacyclohexan-1-ones and (4-Silacyclohexan-1-yl)amines Containing the Silicon Protecting Groups MOP (4-Methoxyphenyl), DMOP (2,4-Dimethoxyphenyl), or TMOP (2,4,6-Trimethoxyphenyl): Versatile Si- and C-Functional Building Blocks for Synthesis
Markus Fischer et al.
ORGANOMETALLICS (2014)
Organosilicon Molecules with Medicinal Applications
Annaliese K. Franz et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Electron densities of bexarotene and disila-bexarotene from invariom application: a comparative study
Peter Luger et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
High-Affinity, Selective s Ligands of the 1,2,3,4-Tetrahydro-1,4′-silaspiro[naphthalene-1,4′-piperidine] Type: Syntheses, Structures, and Pharmacological Properties
Reinhold Tacke et al.
CHEMMEDCHEM (2012)
Disila-analogues of the synthetic retinoids EC23 and TTNN: synthesis, structure and biological evaluation
Josef B. G. Gluyas et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2012)
Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects
Curt A. Dvorak et al.
ACS MEDICINAL CHEMISTRY LETTERS (2012)
3,5-Dihydroxybenzoic Acid, a Specific Agonist for Hydroxycarboxylic Acid 1, Inhibits Lipolysis in Adipocytes
Changlu Liu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Silicon Analogues of the Nonpeptidic GnRH Antagonist AG-045572: Syntheses, Crystal Structure Analyses, and Pharmacological Characterization
Matthew J. Barnes et al.
CHEMMEDCHEM (2011)
ShelXle: a Qt graphical user interface for SHELXL
Christian B. Huebschle et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2011)
Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design
Nicholas A. Meanwell
JOURNAL OF MEDICINAL CHEMISTRY (2011)
In Vitro Metabolism of Haloperidol and Sila-Haloperidol: New Metabolic Pathways Resulting from Carbon/Silicon Exchange
Tove Johansson et al.
DRUG METABOLISM AND DISPOSITION (2010)
Sila-Trifluperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Trifluperidol: Synthesis and Pharmacological Characterization
Reinhold Tacke et al.
ORGANOMETALLICS (2010)
Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81
Changlu Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Role of GPR81 in lactate-mediated reduction of adipose lipolysis
Tian-Quan Cai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Sila-haloperidol, a silicon analogue of the dopamine (D-2) receptor antagonist haloperidol: Synthesis, pharmacological properties, and metabolic fate
Reinhold Tacke et al.
CHEMMEDCHEM (2008)
A short history of SHELX
George M. Sheldrick
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (2008)
Novel therapeutics with enhanced biogical activity generated by the strategic introduction of silicon isosteres into known drug scaffolds
Stephen Gately et al.
DRUG DEVELOPMENT RESEARCH (2007)
Silicon switches of marketed drugs
P. K. Pooni et al.
MINI-REVIEWS IN MEDICINAL CHEMISTRY (2006)
Silanediol protease inhibitors: From conception to validation
SM Sieburth et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2006)
Exploitation of silicon medicinal chemistry in drug discovery
JS Mills et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2004)
Chemistry challenges in lead optimization: silicon isosteres in drug discovery
GA Showell et al.
DRUG DISCOVERY TODAY (2003)
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
S Tunaru et al.
NATURE MEDICINE (2003)
Share Paper
