Journal
PEDIATRICS INTERNATIONAL
Volume 58, Issue 1, Pages 27-33Publisher
WILEY
DOI: 10.1111/ped.12747
Keywords
hypoxic-ischemic encephalopathy; newborn; selective head cooling; whole-body cooling
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Funding
- Mersin University Scientific and Research Foundation [BAP-TF (AHT) 2009-9]
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BackgroundThis study compared selective head cooling (SHC) and whole-body cooling (WBC) in newborns with hypoxic-ischemic encephalopathy (HIE). MethodsWe conducted a prospective randomized small-scale pilot study in newborns with HIE, born after >35weeks of gestation. The patients were randomly assigned to receive SHC or WBC. ResultsThe SHC group consisted of 17 patients, and the WBC group, 12 patients. There was no significant difference in adverse effects related to cooling therapy between the two groups. During the 12month study period, seven patients in the SHC group and four in the WBC group died, but the difference was not significant (P = 0.667). Among the patients alive at 12months after treatment, six in the SHC group and four in the WBC group had severe disabilities; the difference was not significant (P = 0.671). When the composite outcome of death or severe disability was evaluated, the difference between the SHC group (77%, n = 13) and the WBC group (67%, n = 8) was not significant (P = 0.562). Moreover, the number of survivors without disability at 12months after treatment did not differ significantly between the SHC group (n = 3) and the WBC group (n = 4; P = 0.614). ConclusionsThere were no significant differences in adverse effects, 12month neuromotor development, or mortality rate between SHC and WBC in newborns with HIE, born after >35weeks of gestation.
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