4.5 Article

Ligand-Biased and Probe-Dependent Modulation of Chemokine Receptor CXCR3 Signaling by Negative Allosteric Modulators

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Boronic Acids as Probes for Investigation of Allosteric Modulation of the Chemokine Receptor CXCR3

Viachaslau Bernat et al.

ACS CHEMICAL BIOLOGY (2014)

Review Pharmacology & Pharmacy

What does the aromatic ring number mean for drug design?

Simon E. Ward et al.

EXPERT OPINION ON DRUG DISCOVERY (2014)

Article Biochemistry & Molecular Biology

Biased Agonism as a Mechanism for Differential Signaling by Chemokine Receptors

Sudarshan Rajagopal et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biotechnology & Applied Microbiology

OPINION Signalling bias in new drug discovery: detection, quantification and therapeutic impact

Terry Kenakin et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Review Biotechnology & Applied Microbiology

Emerging paradigms in GPCR allostery: implications for drug discovery

Denise Wootten et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Article Biochemistry & Molecular Biology

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

Terry Kenakin et al.

ACS CHEMICAL NEUROSCIENCE (2012)

Article Pharmacology & Pharmacy

Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3

D. J. Scholten et al.

BRITISH JOURNAL OF PHARMACOLOGY (2012)

Article Multidisciplinary Sciences

Chemokine receptor CXCR3 agonist prevents human T-cell migration in a humanized model of arthritic inflammation

Graeme O'Boyle et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Endocrinology & Metabolism

A Pharmacological Primer of Biased Agonism

Bradley T. Andresen

Endocrine Metabolic & Immune Disorders-Drug Targets (2012)

Review Cell Biology

CXCR3 ligands: redundant, collaborative and antagonistic functions

Joanna R. Groom et al.

IMMUNOLOGY AND CELL BIOLOGY (2011)

Article Pharmacology & Pharmacy

Functional Selectivity and Biased Receptor Signaling

Terry Kenakin

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Article Pharmacology & Pharmacy

Quantifying Ligand Bias at Seven-Transmembrane Receptors

Sudarshan Rajagopal et al.

MOLECULAR PHARMACOLOGY (2011)

Review Biochemistry & Molecular Biology

Therapeutic potential of β-arrestin- and G protein-biased agonists

Erin J. Whalen et al.

TRENDS IN MOLECULAR MEDICINE (2011)

Review Biotechnology & Applied Microbiology

Teaching old receptors new tricks: biasing seven-transmembrane receptors

Sudarshan Rajagopal et al.

NATURE REVIEWS DRUG DISCOVERY (2010)

Article Immunology

CXCR3, Inflammation, and Autoimmune Diseases

Stephanie Lacotte et al.

CONTEMPORARY CHALLENGES IN AUTOIMMUNITY (2009)

Article Pharmacology & Pharmacy

AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties

Irina Kalatskaya et al.

MOLECULAR PHARMACOLOGY (2009)

Article Chemistry, Organic

Synthesis of novel 3-heterospiro[5.5]undecanes

Johannes Froehlich et al.

ARKIVOC (2009)

Review Chemistry, Medicinal

Towards small-molecule CXCR3 ligands with clinical potential

Maikel Wijtmans et al.

CHEMMEDCHEM (2008)

Article Chemistry, Medicinal

Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3

Michael Johnson et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2007)

Review Biotechnology & Applied Microbiology

New concepts in drug discovery: Collateral efficacy and permissive antagonism

T Kenakin

NATURE REVIEWS DRUG DISCOVERY (2005)

Article Biochemistry & Molecular Biology

Intracellular domains of CXCR3 that mediate CXCL9, CXCL10, and CXCL11 function

RA Colvin et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Review Pharmacology & Pharmacy

Ligand-selective receptor conformations revisited: the promise and the problem

T Kenakin

TRENDS IN PHARMACOLOGICAL SCIENCES (2003)

Review Pharmacology & Pharmacy

G protein-coupled receptor allosterism and complexing

A Christopoulos et al.

PHARMACOLOGICAL REVIEWS (2002)

Article Immunology

Requirement of the chemokine receptor CXCR3 for acute allograft rejection

WW Hancock et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)