Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 11, Issue 4, Pages 425-436Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201500916
Keywords
efficiency; flow chemistry; flow fine synthesis; multistep flow synthesis; organic synthesis
Categories
Funding
- Japan Society for the Promotion of Science (JSPS)
- Global COE Program
- University of Tokyo
- Japan Science and Technology Agency (JST)
- Ministry of Education, Culture, Sports, Science and Technology (MEXT, Japan)
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The concept of flow fine synthesis, that is, high yielding and selective organic synthesis by flow methods, is described. Some examples of flow fine synthesis of natural products and APIs are discussed. Flow methods have several advantages over batch methods in terms of environmental compatibility, efficiency, and safety. However, synthesis by flow methods is more difficult than synthesis by batch methods. Indeed, it has been considered that synthesis by flow methods can be applicable for the production of simple gasses but that it is difficult to apply to the synthesis of complex molecules such as natural products and APIs. Therefore, organic synthesis of such complex molecules has been conducted by batch methods. On the other hand, syntheses and reactions that attain high yields and high selectivities by flow methods are increasingly reported. Flow methods are leading candidates for the next generation of manufacturing methods that can mitigate environmental concerns toward sustainable society.
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