4.6 Article

Intramolecular C-N Bond Formation under Metal-free Conditions: Synthesis of Indolizines

Journal

CHEMISTRY-AN ASIAN JOURNAL
Volume 10, Issue 4, Pages 853-856

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201403400

Keywords

chalcone; cyclization; heterocycles; indolizines; synthetic methods

Funding

  1. Ministry of Education [MOE2013-T3-1-004]
  2. Nanyang Technological University, Singapore [RG6/13]

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Polysubstituted indolizine derivatives are constructed via intramolecular CN bond formation/CH bond cleavage under metal-free conditions. These methods offer straightforward pathways to transform pyridyl chalcones into a variety of indolizines.

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