Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 10, Issue 4, Pages 844-848Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201403303
Keywords
1; 4-conjugate addition; 4; 4; 4-trifluorocrotonate; aliphatic Grignard reagents; copper catalysis
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Funding
- National Natural Science Foundation of China [21372210]
- National Science Foundation for Young Scientists of China [21202156]
- Fundamental Research Funds for the Central Universities [WK2060190023]
- Natural Science Foundation of Anhui Province [1308085QB37]
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Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in reasonable yields and good enantioselectivities.
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