Journal
PEDIATRIC RESEARCH
Volume 81, Issue 1, Pages 214-226Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/pr.2016.197
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Funding
- Gates Foundation, Seattle, WA [OPP1119263]
- National Institutes of Health, Bethesda, MD [T32 HD07094]
- Bill and Melinda Gates Foundation [OPP1119263] Funding Source: Bill and Melinda Gates Foundation
- Bill & Melinda Gates Foundation - Grand Challenges Explorations Initiative [OPP1119263] Funding Source: researchfish
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Human neurodevelopment requires the organization of neural elements into complex structural and functional networks called the connectome. Emerging data suggest that prenatal exposure to maternal stress plays a role in the wiring, or miswiring, of the developing connectome. Stress-related symptoms are common in women during pregnancy and are risk factors for neurobehavioral disorders ranging from autism spectrum disorder, attention deficit hyperactivity disorder, and addiction, to major depression and schizophrenia. This review focuses on structural and functional connectivity imaging to assess the impact of changes in women's stress-based physiology on the dynamic development of the human connectome in the fetal brain.
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