Journal
PEDIATRIC RESEARCH
Volume 80, Issue 2, Pages 319-325Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/pr.2016.61
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Funding
- Fetal Medicine Foundation, UK
- National Institute for Health Research [NF-SI-0513-10046] Funding Source: researchfish
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Background: This experimental study aims to investigate the impact of combinations of prenatal and postnatal food manipulation on body composition in rat offspring. Methods: On day 12 of gestation, 100 timed pregnant rats were randomized into two nutritional groups: standard laboratory and 50% starved. Pups born to starved mothers were subdivided, based on birthweight (BiW), into fetal growth restricted (FGR) and non-FGR. Pups were born on day 21, cross-fostered, then left undisturbed lactating until the 26th postnatal day when they underwent dual-energy X-ray absorptiometry (DXA) examination. Results: Prenatally control-fed animals had a significantly greater body weight at 26 d postnatally than the prenatally starved groups, irrespective of their postnatal diet (P < 0.001). Postnatal control diet was associated with significantly increased abdominal and total fat in non-FGR compared to FGR rats (P < 0.001). non-FGR/CONTROL rats showed higher values of abdominal fat than prenatally starved animals that were starved postnatally irrespective of their birth weight (P < 0.001). Postnatal control diet significantly increased total bone mineral content (BMC), head BMC, head area, abdominal BMC in non-FGR compared to FGR rats (P < 0.001). Conclusion: Interaction between prenatal and postnatal nutrition affects growth, abdominal adiposity, and bone accrual in Wistar rats' offspring at 26 d of life.
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