Journal
PEDIATRIC CRITICAL CARE MEDICINE
Volume 17, Issue 12, Pages 1157-1169Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PCC.0000000000000970
Keywords
acute kidney injury; acute renal failure; extracorporeal membrane oxygenation; renal dialysis
Categories
Funding
- Bryant Law Firm
- National Institutes of Health [R01 DK13608-01]
- Pediatric and Infant Center for Acute Nephrology
- Children's of Alabama
- University of Alabama at Birmingham School of Medicine
- Department of Pediatrics
- Center for Clinical and Translational Science [UL1TR00165]
Ask authors/readers for more resources
Objective: In a population of neonatal and pediatric patients on extracorporeal membrane oxygenation; to describe the prevalence and timing of acute kidney injury utilizing a consensus acute kidney injury definition and investigate the association of acute kidney injury with outcomes (length of extracorporeal membrane oxygenation and mortality). Design: Multicenter retrospective observational cohort study. Setting: Six pediatric extracorporeal membrane oxygenation centers. Patients: Pediatric patients (age, < 18 yr) on extracorporeal membrane oxygenation at six centers during a period of January 1, 2007, to December 31, 2011. Interventions: None. Measurements and Main Results: Complete data were analyzed for 832 patients on extracorporeal membrane oxygenation. Sixty percent of patients had acute kidney injury utilizing the serum creatinine Kidney Disease Improving Global Outcomes criteria (AKI(SCr)) and 74% had acute kidney injury using the full Kidney Disease Improving Global Outcomes criteria including renal support therapy (AKI(SCr + RST)). Of those who developed acute kidney injury, it was present at extracorporeal membrane oxygenation initiation in a majority of cases (52% AKI(SCr) and 65% AKI(SCr + RST)) and present by 48 hours of extracorporeal membrane oxygenation support in 86% (AKI(SCr)) and 93% (AKI(SCr + RST)). When adjusted for patient age, center of support, mode of support, patient complications and preextracorporeal membrane oxygenation pH, the presence of acute kidney injury by either criteria was associated with a significantly longer duration of extracorporeal membrane oxygenation support (AKI(SCr), 152 vs 110 hr; AKI(SCr + RST), 153 vs 99 hr) and increased adjusted odds of mortality at hospital discharge (AKI(SCr): odds ratio, 1.77; 1.22-2.55 and AKI(SCr + RST): odds ratio, 2.50; 1.61-3.90). With the addition of renal support therapy to the model, acute kidney injury was associated with a longer duration of extracorporeal membrane oxygenation support (AKI(SCr), 149 vs 121 hr) and increased risk of mortality at hospital discharge (AKI(SCr): odds ratio, 1.52; 1.04-2.21). Conclusion: Acute kidney injury is present in 60-74% of neonatal-pediatric patients supported on extracorporeal membrane oxygenation and is present by 48 hours of extracorporeal membrane oxygenation support in 86-93% of cases. Acute kidney injury has a significant association with increased duration of extracorporeal membrane oxygenation support and increased adjusted odds of mortality at hospital discharge.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available