Journal
PEDIATRIC CLINICS OF NORTH AMERICA
Volume 63, Issue 4, Pages 617-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pcl.2016.04.003
Keywords
Cystic fibrosis; Inflammation; Infection; Microbiology; Neutrophil; Biomarker
Categories
Funding
- NHLBI NIH HHS [R01 HL098084, K23 HL114883] Funding Source: Medline
- NIDDK NIH HHS [P30 DK089507, R01 DK095869] Funding Source: Medline
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The earliest descriptions of lung disease in people with cystic fibrosis (CF) showed the involvement of 3 interacting pathophysiologic elements in CF airways: mucus obstruction, inflammation, and infection. Over the past 7 decades, our understanding of CF respiratory microbiology and inflammation has evolved with the introduction of new treatments, increased longevity, and increasingly sophisticated laboratory techniques. This article reviews the current understanding of infection and inflammation and their roles in CF lung disease. It also discusses how this constantly evolving information is used to inform current therapeutic strategies, measures and predictors of disease severity, and research priorities.
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