Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 4, Pages 1248-1252Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201504851
Keywords
arylation; C-H activation; kinetics; reaction mechanisms; ruthenium
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Funding
- European Research Council under the European Community [307535]
- German-Israeli Science Foundation (GIF)
- DFG [SPP 1807]
- CaSuS PhD program
- CNPq
- FAPERJ
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Well-defined ruthenium(II) phosphinous acid (PA) complexes enabled chemo-, site-, and diastereoselective C-H functionalization of arenes and alkenes with ample scope. The outstanding catalytic activity was reflected by catalyst loadings as low as 0.75 mol%, and the most step-economical access reported to date to angiotensin II receptor antagonist blockbuster drugs. Mechanistic studies indicated a kinetically relevant C-X cleavage by a single-electron transfer (SET)-type elementary process, and provided evidence for a PA-assisted C-H ruthenation step.
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