Journal
PEDIATRIC BLOOD & CANCER
Volume 63, Issue 8, Pages 1461-1464Publisher
WILEY
DOI: 10.1002/pbc.26018
Keywords
PD-1/PD-L1 blockade; pediatric cancer; tumor-infiltrating lymphocyte
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Programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) pathway blockade has become a promising therapeutic target in adult cancers. We evaluated PD-L1 expression and tumor-infiltrating CD8(+) T cells in formalin-fixed, paraffin-embedded tumor specimens from 53 untreated pediatric patients with eight cancer types: neuroblastoma, extracranial malignant germ cell tumor, hepatoblastoma, germinoma, medulloblastoma, renal tumor, rhabdomyosarcoma, and atypical teratoid/rhabdoid tumor. One rhabdomyosarcoma with the shortest survival exhibited membranous PD-L1 expression and germinoma contained abundant tumor-infiltrating CD8+ T cells and PD-L1-positive macrophages. The PD-1/PD-L1 pathway tended to be inactive in pediatric cancers. (C) 2016 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.
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