Journal
PEDIATRIC BLOOD & CANCER
Volume 63, Issue 8, Pages 1465-1467Publisher
WILEY
DOI: 10.1002/pbc.26031
Keywords
patterns of failure; pediatric glioblastoma; radiation therapy
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Despite aggressive multimodal therapy for pediatric glioblastoma multiforme (GBM), patient survival remains poor. This retrospective review of patients with GBM aims to evaluate the patterns of failure after radiation therapy (RT). The study included 14 pediatric patients treated with RT at the Children's Hospital of Philadelphia from 2007 to 2015. With a median follow-up of 16.9 months, 13 (92.9%) developed recurrent disease. Of recurrences, nine (69.2%) were infield, three (23.1%) were marginal, and one (7.7%) was distant. The majority of patients treated with adjuvant radiation failed in the region of high-dose RT, indicating the need for improvements in local therapy. (C) 2016 Wiley Periodicals, Inc.
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