Journal
PEDIATRIC BLOOD & CANCER
Volume 63, Issue 9, Pages 1653-1656Publisher
WILEY-BLACKWELL
DOI: 10.1002/pbc.26047
Keywords
B cell; chemotherapy; immune recovery; leukemia; T cell
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Funding
- Foundation of Pediatric Research in Finland
- Finnish Cancer Society
- Foundation of Cancer Research of Moikoinen
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Humoral and cellular immunity were studied in 28 children completing conventional treatment of standard-risk (SR) or intermediate-risk (IR) acute lymphoblastic leukemia (ALL). Both naive and memory B cells were most severely affected and showed slow recovery during the 2-year follow-up, while the T-cell compartment showed only minor changes. Immunoglobulins and IgG subclasses, components, and antibodies against vaccine-preventable diseases were not significantly affected. In conclusion, immune recovery after conventional chemotherapy for SR and IR ALL is marked by B-cell depletion, but otherwise did not show any severe deficiencies in lymphocyte function. (C) 2016 Wiley Periodicals, Inc.
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