Room-Temperature Decarboxylative Couplings of α-Oxocarboxylates with Aryl Halides by Merging Photoredox with Palladium Catalysis

Enabled by merging iridium photoredox catalysis and palladium catalysis, -oxocarboxylate salts can be decarboxylatively coupled with aryl halides to generate aromatic ketones and amides at room temperature. DFT calculations suggest that this reaction proceeds through a Pd-0-Pd-II-Pd-III pathway, in which the Pd-III intermediate is responsible for reoxidizing Ir-II to complete the Ir-III-*Ir-III-Ir-II photoredox cycle.