Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 9, Pages 3585-3588Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201406456
Keywords
carbenes; cascade reactions; chirality transfer; gold catalysis; sigmatropic rearrangement
Categories
Funding
- NSFC [21232007, 21172207]
- Ministry of Education
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An unprecedented gold-catalyzed multiple cascade reaction between 2-alkynyl arylazides and alkynols has been developed, allowing for the step-economical synthesis of pyrroloindolone derivatives with a wide range of structural diversity. In this reaction, the gold complex participates in triple catalysis in tandem fashion. Moreover, the efficient chirality transfer from optically pure alkynol substrates enables facile access to chiral pyrroloindolone derivatives with two stereogenic centers, including a quaternary one, with excellent levels of optical purity.
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