Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 33, Pages 11696-11700Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201502226
Keywords
fluorescence sensing; fluorescent probes; imaging agents; NIR-fluorescent fluorophores; selenocysteine
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Funding
- NSFC [21172063, 21472067]
- University of Jinan
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As selenocysteine (Sec) carries out the majority of the functions of the various Se-containing species in vivo, it is of high importance to develop reliable and rapid assays with biocompatibility to detect Sec. Herein, an NIR fluorescent turn-on probe for highly selective detection of selenol was designed and synthesized. The probe exhibits large turn-on signal upon treatment with selenocysteine (R-SeH), and it was further demonstrated that the new NIR fluorescent probe can be employed to image selenol in living animals.
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