Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 49, Pages 17618-17622Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503809
Keywords
auto-oxidation; C-H functionalization; heterocycles; oxygen; radical reactions
Categories
Funding
- Science and Engineering Research Board, India [SB/S5/GC-08/2014, SB/S1/OC-52/2013]
- CSIR
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An operationally simple and economical method for the direct alkylation of heteroaromatic bases employing readily available aldehydes as alkyl radical precursors and molecular oxygen as a reagent is presented. This simple transformation demonstrates a broad substrate scope with respect to aldehydes and nitrogen heterocycles, enabling the introduction of several medicinally important yet challenging alkyl moieties, such as ethyl, isopropyl, tert-butyl, and cyclohexyl to the different classes of heterocyclic bases in good to excellent yields.
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