Journal
PARKINSONISM & RELATED DISORDERS
Volume 31, Issue -, Pages 116-118Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.parkreldis.2016.07.010
Keywords
EEG; Myoclonus
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Funding
- Sobell Department of Motor Neuroscience and Movement Disorders, University College London, UCL
- Medical Research Council [MC_UU_12024/1, G0901503] Funding Source: researchfish
- Rosetrees Trust [M235-CD3] Funding Source: researchfish
- MRC [G0901503, MR/K022172/1, MC_UU_12024/1] Funding Source: UKRI
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Objective: Recent diagnostic criteria for functional movement disorders have proposed a laboratory supported level of diagnostic certainty where the clinical diagnosis is supported by a positive test. For functional myoclonus the Bereitschaftspotential (BP) is generally accepted as a positive laboratory test. We hypothesised that a different EEG measure, event-related desynchronisation (ERD), might be more effective. Methods: We analysed 20 patients with functional propriospinal myoclonus (fPSM) and 9 controls with organic myoclonus and performed back-averaging for BPs plus time-frequency decomposition to assess ERD and calculated sensitivity and specificity for both techniques. Results: The BP was present in only 25% of patients with fPSM while the majority showed a significant ERD (mean 38 Hz; sensitivity 65%). ERD was significant at the group level (p < 0.001), but not the BP (p > 0.05). Both BP and ERD were absent in our control group. Conclusion: ERD in high-beta may be a useful new test for positive diagnosis of functional myoclonus. (C) 2016 Elsevier Ltd. All rights reserved.
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