Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 12, Pages 4512-+Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201404588
Keywords
dynamic nuclear polarization; membranes; phospholipids; NMR spectroscopy; solid-state NMR spectroscopy
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Funding
- French National Research Agency through the Labex ARCANE [ANR-11-LABX-0003-01]
- programme blanc [ANR-12-BS08-0016-01]
- RTB
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Magic-angle spinning dynamic nuclear polarization (MAS-DNP) has been proven to be a powerful technique to enhance the sensitivity of solid-state NMR (SSNMR) in a wide range of systems. Here, we show that DNP can be used to polarize lipids using a lipid-anchored polarizing agent. More specifically, we introduce a C16-functionalized biradical, which allows localization of the polarizing agents in the lipid bilayer and DNP experiments to be performed in the absence of excess cryo-protectant molecules (glycerol, dimethyl sulfoxide, etc.). This constitutes another original example of the matrix-free DNP approach that we recently introduced.
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