Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 16, Pages 6074-6078Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201500551
Keywords
alkenes; cross-coupling; fluoroalkylation; fluorine; palladium
Categories
Funding
- National Basic Research Program of China [2012CB821600]
- National Natural Science Foundation of China [21172245, 21172244, 21372247, 21421002]
- SIOC
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Pd-catalyzed difluoromethylation of di-, tri- or tetra-substituted vinyl bromides, triflates, tosylates and nonaflates under mild conditions is described. The reaction tolerates a wide range of functional groups, such as bromide, chloride, fluoride, ester, amine, nitrile, and protected carbonyl, thus providing a general route for the preparation of difluoromethylated alkenes.
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