Journal
PARASITE IMMUNOLOGY
Volume 39, Issue 1, Pages -Publisher
WILEY
DOI: 10.1111/pim.12386
Keywords
antibody; blood stage; liver stage; T-cell response; whole-killed blood-stage lysate vaccine
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Funding
- National Science Foundation of China
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Although the attenuated sporozoite is the most efficient vaccine to prevent infection with the malaria parasite, the limitation of a source of sterile sporozoites greatly hampers its application. In this study, we found that the whole-killed, blood-stage lysate vaccine could confer protection against the blood stage as well as the liver stage. Although the protective immunity induced by the whole-organism vaccine against the blood stage is dependent on parasite-specific CD4(+) T-cell responses and antibodies, in mice immunized with the whole-killed, blood-stage lysate vaccine, CD8(+), but not CD4(+) effector T-cell responses greatly contributed to protection against the liver stage. Thus, our data suggested that the whole-killed, blood-stage lysate vaccine could be an alternative promising strategy to prevent malaria infection and to reduce the morbidity and mortality of patients with malaria.
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