Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 4, Pages 1228-1232Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503139
Keywords
alpha-helix; cobalt; paramagnetic NMR spectroscopy; protein structures; pseudo-contact shifts
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Funding
- Australian Research Council [FT130100838, DP120100561, DP150100383]
- Australian Research Council [FT130100838] Funding Source: Australian Research Council
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Coupling two copies of an iminodiacetic acidcysteine hybrid ligand to a pair of cysteine residues positioned in an i, i+4 arrangement within a protein alpha-helix leads to generation of an EDTA-like metal ion-binding motif. Rigid binding of a Co-II ion by this motif produces pseudo-contact shifts suitable for paramagnetic NMR structural studies.
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