Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 8, Pages 3178-3182Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201406366
Keywords
cell cultures; gels; polymers; self-assembly; supramolecular chemistry
Categories
Funding
- Leibniz Gemeinschaft [SAW-2011-IPF-2/380032]
- Bundesministerium fur Bildung und Forschung (BMBF) [03Z2EN12, 03Z2E511]
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We report a novel, noncovalent hydrogel system crosslinked solely by receptor-ligand interactions between biotin and avidin. The simple hydrogel synthesis and functionalization together with the widespread use of biotinylated ligands in biosciences make this versatile system suitable for many applications. The gels possess a range of tunable physical properties, including stiffness, lifetime, and swelling. The erosion rates, unexpectedly fast compared to the kinetic parameters for biotin-avidin, are explored in terms of stretching tensions on the polymers, a concept well-known on the single-molecule level, but largely unexplored in supramolecular systems. As proof of utility, the gels were functionalized with different peptide sequences to control human mesenchymal stromal cell morphology in 3D culture.
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