Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 36, Pages 12616-12619Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201501552
Keywords
hyperpolarization; NMR spectroscopy; peptides; signal amplification by reversible exchange; signal enhancement
Categories
Funding
- Polish National Science Center [SONATA-2011/03/D/ST4/02345]
- Deutsche Forschungsgemeinschaft [Bu-911-22-1]
- European Union/European Regional Development Fund
Ask authors/readers for more resources
Signal amplification by reversible exchange (SABRE) can enhance nuclear magnetic resonance signals by several orders of magnitude. However, until now this was limited to a small number of model target molecules. Here, a new convenient method for SABRE activation applicable to a variety of synthetic model oligopeptides is demonstrated. For the first time, a highly SABRE-active pyridine-based biocompatible molecular framework is incorporated into synthetic oligopeptides. The SABRE activity is preserved, demonstrating the importance of such earmarking. Finally, a crucial exchange process responsible for SABRE activity is identified and discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available