Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 36, Pages 12804-12808Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201501909
Keywords
alkaloids; asymmetric synthesis; lactams; nitrogen heterocycles; total synthesis
Categories
Funding
- Spanish Ministry of Economy and Competitiveness [CTQ2012-35250]
- AGAUR, Generalitat de Catalunya [2014SGR155]
- MINECO
Ask authors/readers for more resources
The marine alkaloids (-)-lepadins A-C and (+)-lepadin D, belonging to two diastereoisomeric series, were synthesized from an (R)-phenylglycinol-derived tricyclic lactam via a common cis-decahydroquinoline intermediate. Crucial aspects of the synthesis are the stereochemical control in the assembly of the cis-decahydroquinoline platform, in the introduction of the C2 methyl and C3 hydroxy substituents, and in the generation of the C5 stereocenter.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
