Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 22, Pages 8237-8241Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201500660
Keywords
aldehydes; antiproliferation; asymmetric synthesis; nitrogen heterocycles; organocatalysis
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Funding
- Spanish Government [CTQ-2012-12168]
- MICINN
- Universidad Autonoma of Madrid
- EU [FP7-REGPOT-2012-CT2012-31637-IMBRAIN]
- European Regional Development Fund (FEDER)
- Spanish Instituto de Salud Carlos III [PI11/00840]
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An asymmetric synthesis of diheteroarylalkanals through one-pot dienamine and Friedel-Crafts reaction is presented. The reaction tolerates a large variety of substituents at different positions of the starting aldehyde and also in the indole nucleophile, and a range of diheterocyclic alkanals can be achieved. Furthermore, we have studied the antiproliferative activity of these new compounds in representative cancer tumor cell lines.
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