Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 17, Pages 6367-6370Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201406503
Keywords
alkynes; calcium; carboarylation; synthetic methods; tetrasubstituted alkenes
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Funding
- China Scholarship Council (CSC)
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The first transition-metal-free carboarylation of alkynes with commercial and readily available alcohols as alkylating agents was realized in the presence of an environmentally benign calcium catalyst. Thereby, a novel protocol for the one-step synthesis of highly congested, all-carbon tetrasubstituted alkenes, as incorporated in potentially bioactive, complex dihydronaphthalene, chromene and dihydroquinoline structures, is provided. The reaction features an unprecedented, particularly wide substrate scope, good functional-group tolerance and simple experimental operation under mild reaction conditions.
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