Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 16, Pages 6048-6051Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201406542
Keywords
aromatic nucleophilic substitution; density functional calculations; mass spectrometry; substitution of hydrogen
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Funding
- National Science Centre, Poland [UMO-2012/05/B/ST4/01161]
- Interdisciplinary Centre for Mathematical and Computational Modeling (ICM) in Warsaw [G50-2]
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The mechanism of intramolecular gas-phase reactions of N-(2-X-5-nitrophenyl)-N-methylacetamide carbanions (X=H, F, Cl) has been studied using negative ion electrospray mass spectrometry ((-)ESI-MS) technique and modelled computationally. It was proven that all three anions form cyclic sigma(H) adducts, which undergo elimination of water. In the case of X=F, formation of the sigma(F) adduct, leading to SNAr reaction, was a competing process. This is the first proof that also in the gas phase formation of sigma(H) adduct proceeds faster than sigma(X) adduct and only when X=F, rates of these two processes are comparable. The experimental results are in full agreement with quantum chemical calculations.
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