4.6 Article

Recent Developments in the Trifluoromethylation of Alkynes

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 21, Pages 7648-7661

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201406432

Keywords

alkyne; difunctionalization; radical reactions; synthetic methods; trifluoromethylation

Funding

  1. National Science Foundation [NSF21272101, 21472073, 21472074]

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In the last few years, the development of versatile methodologies to incorporate trifluoromethyl groups into organic molecules has attracted significant attention in synthetic chemistry. This review gives an overview over the development on the trifluoromethylation of alkynes, which have not been solely discussed before. Formation of diverse C(sp, sp(2), sp(3))CF3 bonds are all covered in this review.

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