Journal
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Volume 2016, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2016/9025627
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- Department of Chemistry at Illinois State University
- CNRS
- Universite de Versailles St Quentin
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Leishmaniasis is a disease that is a significant problem for people, especially in tropical regions of the world. Current drug therapies to treat the disease are expensive, not very effective, and/or of significant side effects. A series of alkyl bisphosphonate compounds and one amino bisphosphonate compound, as well as alendronate and zoledronate, were tested as potential agents against Leishmania tarentolae. Also, two polyoxometalates (POMs) with nitrogen-containing bisphosphonate ligands, vanadium/alendronate (V-5(Ale)(2)) and vanadium/zoledronate (V-3(Zol)(3)), were tested against L. tarentolae and compared to the results of the alendronate and zoledronate ligands alone. Of the compounds evaluated in this study, the V-5(Ale)(2) and V-3(Zol)(3) complexes were most effective in inhibiting the growth of L. tarentolae. The V-5(Ale)(2) complex had a larger impact on cell growth than either alendronate or orthovanadate alone, whereas zoledronate itself has a significant effect on cell growth, which may contribute to the activity of the V-3(Zol)(3) complex.
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