Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 51, Pages 18551-18556Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503830
Keywords
fluorescence; logic gate; photodynamic therapy; photosensitizer; phthalocyanine
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Funding
- People Programme (Marie Curie Actions) of the European Union's Seventh Framework Programme FP7-PEOPLE-ITN under REA grant [GA 316975]
- Spanish Ministry of Economy (MINECO)
- EU (CosmoPHOS-nano) [FP7-NMP-2012-6, 310337-2, FP7-ENERGY-2012-J, 309194-2]
- Spanish MINECO [CTQ-2014-52869-P, CTQ-2014-53673-P]
- CAM (FOTOCARBON) [S2013/MIT-2841]
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Herein we describe a photosensitizer (PS) with the capacity to perform multiple logic operations based on a pyrene-containing phthalocyanine (Pc) derivative. The system presents three output signals (fluorescence at 377 and 683 nm, and singlet oxygen (O-1(2)) production), which are dependent on three inputs: two chemical (concentration of dithiothreitol (DTT) and acidic pH) and one physical (visible light above 530 nm for O-1(2) sensitization). The multi-input/multioutput nature of this PS leads to single-, double-, and triple-mode activation pathways of its fluorescent and photodynamic functions, through the interplay of various interrelated AND, ID, and INHIBIT gates. Dual fluorescence emissions are potentially useful for orthogonal optical imaging protocols while O-1(2) is the main reactive species in photodynamic therapy (PDT). We thus expect that this kind of PS logic system will be of great interest for multimodal cellular imaging and therapeutic applications.
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