Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 24, Issue 3, Pages 458-464Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2015.09.013
Keywords
Knee osteoarthritis; Magnetic resonance imaging; Cohort studies; Incidence
Categories
Funding
- NIH [U01-AG18820, U01-AG18832, U01-AG18947, U01-AG19069, P60-AR47785, R01-AR051568, R01-HD43500]
- NIHR Biomedical Research Unit at the University of Manchester, UK
Ask authors/readers for more resources
Objective: To identify the independent relation of synovitis with incident radiographic knee osteoarthritis (OA) after adjusting for other structural factors known to cause synovitis. Design: We examined MRIs from knees that developed incident radiographic OA from the Multicenter Osteoarthritis Study (MOST) and compared these case knees with controls that did not develop OA. We examined baseline MRIs for knees developing OA at any time up to 84 months follow-up. We scored lesions in cartilage, meniscus, bone marrow and synovitis. Synovitis scores were summed (0-9) across three regions, suprapatellar, infrapatellar and intercondylar region, each of which was scored 0-3. After bivariate analyses examining each factor's association with incidence, we carried out multivariable regression analyses adjusting for age, sex, BMI, alignment and cartilage and meniscal damage. Results: We studied 239 case and 731 control knees. In bivariate analyses, cartilage lesions, meniscal damage, synovitis and bone marrow lesions were all risk factors for OA. After multivariable analyses, synovitis was associated with incident OA. A higher synovitis score increased the risk of incident OA (adjusted OR per unit increase 1.1; (95% CI 1.0, 1.2, P =.02)), but increased risk was associated only with synovitis scores of >= 3 (adjusted OR 1.6; 95% CI 1.2, 2.1, P =.003). Conclusions: Synovitis, especially when there is a substantial volume within the knee, is an independent cause of OA. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available