Formation of the Main Cores Present in Natural Products by Tandem Additions

A rapid route to 5,5- and 5,6-bicyclic systems is provided by an 1,3-alkyl-shift process mediated by a hyper-valent iodine reagent on aromatics. The structures obtained contain several unsaturations with different behaviors and reactivities. Such diversity allows further elaborations for the rapid formation of compact systems present in a variety of natural products. The potential for further transformations has been demonstrated by performing a double Michael addition. This cyclization process is regio- and stereoselective due to the presence of a former benzylic substituent. Furthermore, an extension of this approach has been accomplished on indole derivatives.