Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 1, Pages 97-100Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503748
Keywords
carbonic anhydrases; drug design; inhibitors; theoretical calculations; X-ray structures
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Funding
- CNR-DSB Progetto Bandiera InterOmics
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Carboxylates are the least investigated class of inhibitors of carbonic anhydrases (CAs). Here we explain the versatility of binding of these molecules to CAs by examining a new adduct of hCA II with N-carboxymethylsaccharin.
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