Journal
OSTEOARTHRITIS AND CARTILAGE
Volume 24, Issue 11, Pages 1910-1917Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.joca.2016.06.012
Keywords
Pain behaviour; Monosodium iodoacetate; Synovitis; Knee OA; Structural pathology
Categories
Funding
- Arthritis Research UK [20777]
- LNN studentship by the University of Nottingham
Ask authors/readers for more resources
Objectives: To address the hypothesis that different types of established osteoarthritis ( OA) pain behaviours have associations with different aspects of articular pathology, we investigated the relationship between structural knee joint pathology and pain behaviour following injection of a low vs a high dose of monosodium iodoacetate ( MIA) in the rat. Methods: Rats received a single intra-articular injection of 0.1 mg or 1 mg MIA or saline ( control). Pain behaviour ( hind limb weight bearing asymmetry ( WB) and hindpaw withdrawal threshold ( PWT) to punctate stimulation) was assessed. Cartilage and synovium were examined by macroscopic visualisation of articular surfaces and histopathology. Results: Both doses of MIA lowered PWTs, 1 mg MIA also resulted in WB asymmetry. Both doses were associated with cartilage macroscopic appearance, proteoglycan loss, abnormal chondrocyte morphology, increased numbers of vessels crossing the osteochondral junction, synovitis and macrophage infiltration into the synovium. PWTs were more strongly associated with chondrocyte morphology, synovitis and macrophage infiltration than with loss of cartilage surface integrity. Conclusions: Both pain behaviours were associated with OA structural severity and synovitis. Differences in pain phenotype following low vs higher dose of MIA were identified despite similar structural pathology. OA structural pathology as traditionally measured only partially explains the MIA-induced pain phenotype. (C) 2016 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International. This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available