4.5 Article

Rhodium-Catalyzed Oxidative Coupling of Benzoic Acids with Terminal Alkynes: An Efficient Access to 3-Ylidenephthalides

Journal

ORGANOMETALLICS
Volume 35, Issue 10, Pages 1350-1353

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.6b00107

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Funding

  1. National NSF of China [21432005, 21321061]
  2. Comprehensive Training Platform of Specialized Laboratory, College of Chemistry, Sichuan University

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Herein we disclose the first example of transition-metal-catalyzed oxidative coupling/annulation of simple benzoic acids with terminal alkynes via C-H activation. A range of aromatic carboxylic acids and terminal alkynes have been found to be viable substrates in this reaction, providing a simple and efficient method for the synthesis of diverse 3-ylidenephthalides with complete Z selectivity.

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