Journal
ORGANOMETALLICS
Volume 35, Issue 17, Pages 2930-2937Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.organomet.6b00478
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Funding
- SERB (DST) of India [SR/S1/IC-25/2012]
- UGC, New Delhi, India
- IISER Kolkata
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A base-metal, Fe(0)-catalyzed hydrosilylation of imines to obtain amines is reported here which outperforms its noble-metal congeners with the highest TON of 17000. The catalyst, (aNHC)Fe(CO)(4), works under very mild conditions, with extremely low catalyst loading (down to 0.005 mol %), and exhibits excellent chemoselectivity. The facile nature of the imine reduction under mild conditions has been further demonstrated by reducing imines towards expensive commercial amines and biologically important N-alkylated sugars, which are difficult to achieve otherwise. A mechanistic pathway and the source of chemoselectivity for imine hydrosilylation have been proposed on the basis of the well-defined catalyst and isolable intermediates along the catalytic cycle.
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