Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 20, Issue 7, Pages 1297-1304Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.6b00118
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- Ministry of Science, Research and the Arts of the State Baden-Wurttemberg, Germany (MWK) [2014.001]
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The synthesis of hydroperoxymethyl oxazoles by oxidation of alkylideneoxazoles with molecular oxygen was implemented in a microstructured reactor for increased safety and larger-scale applications. Elaborate studies on the influence of pressure and temperature were performed, and the apparent activation energy for the oxidation reaction was determined. Elevated temperatures up to 100 degrees C and pressures up to 18 bar(a) led to a conversion rate of approximately 90% within 4 h of the reaction time, thus displaying the high potential and beneficial effect of using a microreactor setup with liquid recycle loop for this oxidation. The in situ reduction of the generated hydroperoxide functionality shows the capability of this setup for follow-up transformations.
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