Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 20, Issue 6, Pages 1104-1107Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.6b00133
Keywords
-
Categories
Ask authors/readers for more resources
A general selective and environmentally friendly method for the formation of amide bonds using a surfactant in water as medium is described. The use of readily available 1-ethy1-3-(3-(dimethylamino)propyl)-carbodiimide (EDC) and hydroxybenzotriazol (HOBt) as a coupling system, N-methylmorpholine (NMM), and TPGS-750-M represents mild conditions allowing for chemoselective amidation of unprotected amino alcohols. Comparative results with classical polar aprotic solvents such as dimethylformamide or acetonitrile are presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available