Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 21, Issue 27, Pages 9825-9832Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201500909
Keywords
electrochemistry; luminescence; metal-organic frameworks; sensors; synthesis design
Categories
Funding
- NNSF of China [51473136, 21275119]
- China Postdoctoral Science Foundation [2014M550454]
- Fundamental Research Funds for the Central Universities [XDJK2014C138]
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Novel luminescence-functionalized metal-organic frameworks (MOFs) with superior electrogenerated chemiluminescence (ECL) properties were synthesized based on zinc ions as the central ions and tris(4,4'-dicarboxylicacid-2,2'-bipyridyl) ruthenium(II) dichloride ([Ru(dcbpy)(3)](2+)) as the ligands. For potential applications, the synthesized MOFs were used to fabricate a signal-on ECL immunosensor for the detection of N-terminal pro-B-type natriuretic peptide NT-proBNP). As expected, enhanced ECL signals were obtained through a simple fabrication strategy because luminescence-functionalized MOFs not only effectively increased the loading of [Ru(dcbpy)(3)](2+), but also served as a loading platform in the ECL immunosensor. Furthermore, the proposed ECL immunosensor had a wide linear range from 5 pg mL(-1) to 25 ngm L-1 and a relatively low detection limit of 1.67 pg mL(-1) (signal/noise=3). The results indicated that luminescence-functionalized MOFs provided a novel amplification strategy in the construction of ECL immunosensors and might have great prospects for application in bioanalysis.
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