4.8 Article

Cp*CoIII-Catalyzed Dehydrative C-H Allylation of 6-Arylpurines and Aromatic Amides Using Allyl Alcohols in Fluorinated Alcohols

Journal

ORGANIC LETTERS
Volume 18, Issue 9, Pages 2216-2219

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00846

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Funding

  1. ACT-C from JST
  2. Scientific Research on Innovative Area from MEXT
  3. JSPS
  4. Asahi Glass Foundation
  5. Grants-in-Aid for Scientific Research [15H05802, 15H05993] Funding Source: KAKEN

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Cp*Co-III-catalyzed C-H allylation of various aromatic C-H bonds using allyl alcohols as allylating reagents is described. Improved reaction conditions using fluorinated alcohol solvents afforded efficient directed C-H allylation of 6-arylpurines, benzamides, and a synthetically useful Weinreb amide with good functional group compatibility.

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