4.8 Article

Synthesis of Quinoline-Fused 1-Benzazepines through a Mannich-Type Reaction of a C,N-Bisnucleophile Generated from 2-Aminobenzaldehyde and 2-Methylindole

Journal

ORGANIC LETTERS
Volume 18, Issue 3, Pages 364-367

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03287

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Funding

  1. National Natural Science Foundation of China [21173089, 21373093]
  2. fundamental research funds for the central universities in China [2014ZZGH019]

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Various quinoline-fused 1-benzazepine derivatives were synthesized using the C,N-1,6-bisnucleophile generated in situ from o-aminobenzaldehyde and 2-methylindole through a Mannich-type reaction.

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