Journal
ORGANIC LETTERS
Volume 18, Issue 15, Pages 3722-3725Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01746
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Funding
- NSF of China [21572072]
- Science and Technology Innovation Program of Universities in Henan Province [16HASTIT007]
- Zhengzhou University
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A facile and efficient protocol for palladium-catalyzed C8-selective acylation of quinoline N-oxides with alpha-oxocarboxylic acids has been developed. In this approach, N-oxide was utilized as a stepping stone for the remote C-H functionalization. The reaction proceeded efficiently under mild reaction conditions with excellent regioselectivity and broad functional group tolerance.
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