Journal
ORGANIC LETTERS
Volume 18, Issue 20, Pages 5412-5415Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b02814
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [21425415, 21274058]
- National Basic Research Program of China [2015CB856303]
Ask authors/readers for more resources
Despite their tremendous synthetic and pharmaceutical utility, primary azaaromatic amines remain elusive for access based on a generally applicable C-H functionalization strategy. An oxadiazolone-enabled approach is reported for convenient entry into N-Auisubstituted 1-aminoisoquinolines through Co (III)-catalyzed redox-neutral, step-, atom-, and purification-economic C-H functionalization with alkynes. A N-15 labeling experiment reveals the effectiveness of both oxadiazolone N atoms as directing sites. The installed primary amine can be harnessed as a synthetically useful handle for attachment of divergent appendages.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available