Journal
ORGANIC LETTERS
Volume 18, Issue 24, Pages 6496-6499Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03435
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- NSFC [21672101, 81530089, 81421091, 21402090, 21661140001, 21303086]
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Autoimmune and inflammatory diseases are associated with inappropriate activation of the NOD-like receptor protein 3 (NLRP3) inflammasome, but suitable inhibitors against such improper activations remain scarce. Here, spirodalesol (1) from Daldinia eschscholzii was structurally characterized and is biosynthetically proposed as an NLRP3 inflammasome activation inhibitor with an unprecedented carbon skeleton.
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