Journal
ORGANIC LETTERS
Volume 18, Issue 2, Pages 280-283Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.5b03437
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- CSIR-CDRI
- UGC-New Delhi
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An efficient, three-component domino reaction between aldehydes, amines, and the Bestmann-Ohira reagent is reported that enables a general, mild, and straightforward access to 1,4,5-trisubstituted 1,2,3-triazolines and triazoles. The reaction proceeds through a domino-condensation/1,3-dipolar cycloaddition sequence to afford the triazoline derivatives with excellent diastereoselectivity. Moreover, when both amine and aldehyde employed for this reaction are aromatic, a spontaneous oxidation afforded 1,4,5-trisubstituted triazoles in moderate yields.
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