4.8 Article

Palladium-Catalyzed Nitration of Meyer-Schuster Intermediates with tBuONO as Nitrogen Source at Ambient Temperature

Journal

ORGANIC LETTERS
Volume 18, Issue 15, Pages 3702-3705

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01740

Keywords

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Funding

  1. National Natural Science Foundation of China [21202049]
  2. Recruitment Program of Global Experts (1000 Talents Plan)
  3. Natural Science Foundation of Fujian Province [2016J01064]
  4. Fujian Hundred Talents Plan and Program of Innovative Research Team of Huaqiao University [Z14X0047]
  5. Graduate Innovation Fund of Huaqiao University

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A novel domino palladium-catalyzed nitration of Meyer-Schuster intermediates which were generated in situ from propargylic alcohols was developed, by the use of t-BuONO, leading to alpha-nitro enones in good to excellent yields at room temperature with a broad functional group tolerance.

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