4.8 Article

Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

Journal

ORGANIC LETTERS
Volume 18, Issue 12, Pages 2808-2811

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01023

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Funding

  1. University of Antwerp
  2. Research Foundation-Flanders (FWO)
  3. Hercules Foundation
  4. Netherlands Organization for Scientific Research (NWO)
  5. Innovative Medicines Initiative Joint Undertaking project CHEM21 (European Union's) [115360]
  6. Innovative Medicines Initiative Joint Undertaking project CHEM21 (EFPIA companies')
  7. European Union's Horizon research and innovation programme under the Marie Sklodowska-Curie Grant [657883]
  8. Marie Curie Actions (MSCA) [657883] Funding Source: Marie Curie Actions (MSCA)

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A new method for the synthesis of secondary thiocarbamates from readily available isocyanides and thiosulfonates with broad functional group tolerance is reported. The reaction proceeds under mild reaction conditions in isopropanol and is catalyzed by inexpensive sodium iodide.

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