Journal
ORGANIC LETTERS
Volume 18, Issue 8, Pages 1832-1835Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b00562
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Funding
- National Natural Science Foundation of China [21502220]
- 100 Talents Project of CAS
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Regarding targeted disruption of epigenetic regulators, histone methyltransferase and deacetylase in a plant endophytic fungus Pestalotiopsis fici have been uncovered as an unexplored chemical repertoire. Manipulation of epigenetic regulators led to the isolation of 15 new polyketides, including pestaloficiols T-W (1-3 and 5), as well as 11 macrodiolide ficiolides A-K (6-16). Ficiolide K (16) was found to contain a very rare 1,6-anhydro-pyranose moiety. Finally, the biosynthetic origin of macrodiolide was characterized by isotope-labeling experiments.
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